Abstract: The field trials were conducted to study effects of combined application of nitrogen(N) and potassium(K) on nutrient uptake,grain yield and quality of weak gluten wheat on low-K and medium-K soils.The results showed that combination of N and K fertilizers could increase N and K content and absorption of wheat plant.There was a positive interaction of N and K on nutrient absorption.The rational combination of N and K fertilizer increased the yield of weak gluten wheat significantly.The treatment of N180K150 achieved the maximum yield of 5023 kg/ha in low-K soil while the N180K90 obtained maximum yield of 5145 kg/ha in medium-K soil.The yield response of wheat to N was more significant than that of potassium.The significant positive interaction of N and K fertilizer on the grain yield was found in low-K soil.The quality of weak gluten wheat was decreased notably with the increase of N rate in two soils.There was interaction between N and K on quality of weak gluten wheat while the effect of single K was not obvious.The correlation coefficients of N and K content with grain yield or quality were better at jointing and heading stages or at heading and filling stages,respectively.The quality of weak gluten wheat could be improved either by reducing N rate properly or increasing basal N and K ratios.