Abstract: A solution experiment was conducted to study the iron (Fe) efficiency of six wheat genotypes, Hanxuan 10, Lumai 14, Xiaoyan 54, Jing 411, Luofulin and Zhongguochun. The results showed that there are genotypic differences in Fe efficiency among different wheat genotypes. Among the tested genotypes, the genotype Zhongguochun has the highest Fe efficiency, while Hanxuan 10 has the lowest under this experimental condition. There were no significant correlations between wheat grain Fe concentration and Fe efficiency during the early growth stage under the condition of this experiment. Further investigation indicates that Fe uptake is the major contributor to Fe efficiency, while root surface is the most important factor affecting Fe uptake.