Abstract: The relationship between grain outputs of fertilizer in the Huang-Huai-Hai plain was studied by use statistic data, inquiring farmer, and field trial. Gaocheng County was a case study. The results shown that there will be great potential capacity to increase grain output in production, and the grain yield are positive related with the amount of fertilizer markedly as a whole, but there have been imbalance and inconsequence in using of fertilizer. It is essentially important to improve fertilizer use efficiency for save resources as well as increase yield. To increase grain output should to arrange fertilizer by planning as a whole rationally rather than to increase its amount. The trial indicated that the yield were significantly difference at different proportion of N, P and K, at the condition of all the straw andstalk return to field in wheat-corn cropping system. The effects of N and P on increasing yield on wheat more evidence than that on corn. The yields were not increased with using K.