Abstract: Low temperature stress is a common limiting factor for high quality and high yield of wheat production, many researches have been carried out to alleviate the adverse impact by application of exogenous chemical agents. We searched the published literatures related to low-temperature chemical control in wheat from January 1 of 2000 to December 31 of 2022. According to the mechanism, the exogenous chemical agents regulate the low temperature tolerance of wheat through five paths, i.e. improving photosynthetic efficiency, inducing and synthesizing osmotic adjustment substances, increasing antioxidant enzyme activity, stimulating the synthesis of hormone and up-expressing of cold tolerance genes. We also focused on the progress in production of chemical agents corresponded to each category of the mechanism. In the future, more researches are needed for fully understand the mechanism of exogenous chemical control regulators, efficient application of chemical agents by suitable application period, dosage and method, and further optimize the research and procession technology of chemical agent production, aiming to achieve efficient prevention and mitigation of the adverse impact caused by low temperature on wheat production.